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Importantly, it has also been observed that in the treatment of head and neck squamous cell carcinoma cell lines by EGFR inhibitor, gefitinib decreased the cell number in the SP population, which was associated with a decrease of the ABC transporter on the cell surface.
Similarly, the occurrence of EGFR gene polymorphisms or mutations may also influence the response to therapeutic cancer treatment and outcome of patients.
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For the treatment of metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.
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HercepTest is a semi-quantitative immunocytochemical assay to determine HER2 protein overexpression in breast cancer tissues routinely processed for histological evaluation and formalin-fixed, paraffin-embedded cancer tissue from patients with metastatic gastric or gastroesophageal junction adenocarcinoma.
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Targeted treatments for advanced non-small cell lung cancer; Sunitinib (Sutent) works by cutting off blood supply and blockingnthe cancer cells their ability to grow.
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It is indicated for use as an adjunct to existing clinical and pathologic information currently used as prognostic indicators in the risk stratification of breast cancer in patients who have had a priori invasive, localized breast carcinoma and who are lymph node-negative.
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HercepTest is indicated as an aid in the assessment of breast and gastric cancer patients for whom Herceptin (trastuzumab) treatment is being considered and for breast cancer patients for whom PERJETA (pertuzumab) treatment or KADCYLA (ado-trastuzumab emtansine) treatment is being considered (see Herceptin, PERJETA and KADCYLA package inserts).
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If the cancer is localized to the anus and pelvic lymph nodes, it may be used in combination with radiation therapy to achieve the best chance of killing all of the cancer cells (see "Combined Modality (Chemoradiotherapy).
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Hypercalcemia: Some lung cancers produce substances that remove calcium from bone and release it into the bloodstream, causing a condition called hypercalcemia.
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